Description and instructions of Melitor

In the modern world, many people are familiar with a state such as depression. This is a kind of mental disorder, which is characterized by a decrease in mood, loss of the ability to rejoice, and also a violation of thinking (in the negative direction) and motor inhibition.

During depression, a person's self-esteem is significantly reduced, and there is a loss of interest in the usual activities and life in general. In some cases, the patient begins to abuse alcoholic beverages or any psychotropic substances. In addition, a person who has been depressed for a long time is prone to suicide. Therefore, it is necessary to leave this state. To do this, you need to contact an experienced doctor.

A large number of pharmacological companies specialize in the production of so-called antidepressants. These are psychotropic medications that have a direct effect on the level of neurotransmitters, including dopamine and serotonin. In a depressed person, such a remedy improves mood, reduces lethargy, relieves depression, eliminates anxiety, apathy and emotional tension.

One of the most popular antidepressants is the drug "Melitor". Instructions for use, reviews about the drug will be presented below.

Description, form of production, composition, packaging

Medication "Melitor", the instruction on which application is enclosed in cardboard packing, is issued in the form of tablets. They have an oblong shape and an orange-yellow color. Also, the drug is film-coated. On one side of the tablet is an imprint of the company logo.

In the sale of tablets come in blisters for 14 pieces.

What substances contain the medicine "Melitor"? Instructions for use asserts that its active ingredient is agomelatine. Also in the composition of the tablets are additional elements in the form of stearic acid, lactose monohydrate, povidone, corn starch, sodium starch glycolate (type A), anhydrous colloidal silicon dioxide and magnesium stearate.

Pharmacology

"Melitor" tablets (instructions for use are described below) are an antidepressant that acts on the nervous system and effectively manifests itself in various forms of depression. In addition, this drug is often taken with desynchronization of circadian rhythms, anxiety and stress.

The active substance of the drug in question is a melatonergic agonist of the MT2 and MT1 receptors, as well as a 5-HT2c receptor antagonist. This agent has no affinity for choline, histamine, dopaminergic, beta-and alpha-adrenergic and benzodiazepine receptors, and also does not change the degree of capture of monoamines. This drug synchronizes circadian rhythms, normalizes the structure of sleep, stimulates the formation of melatonin and facilitates falling asleep.

When using a medicament to treat people with depression, the slow-wave sleep phase is prolonged. As for the phase of fast sleep, it is not subject to any changes.

It should also be noted that this agent can stimulate the release of norepinephrine and dopamine in the cortex of the frontal lobe of the brain. In this case, agomelatine does not change the level of extracellular serotonin.

Properties of the medicine

What features are inherent in the drug "Melitor"? The instruction, the reviews say that in healthy volunteers it did not have a negative effect on memory, body weight, ability to concentrate, AD, sexual function and heart rate. In addition, agomelatine is not addictive. After the termination of treatment the withdrawal syndrome was not developed.

Kinetics

What are the kinetic properties of the medication under consideration? What does the instruction say about this? "Melitor" is well absorbed from the digestive tract. Its absolute bioavailability is 3%. But, depending on the characteristics of a person, significant fluctuations are possible. For example, in women, the bioavailability of the drug is higher than that of men. Moreover, smoking reduces this indicator, and the intake of oral contraceptives, on the contrary, increases.

The peak concentration of the active component in the blood is observed 70-100 minutes after oral administration. The antidepressant is characterized by a high degree of association with plasma proteins (up to 95%).

Metabolism means occurs in the liver with the formation of inactive compounds. The medicine is excreted by the kidneys (about 80%) for two hours.

Indications

What is the medicine for? Melitor? The instruction informs, that the given preparation is intended for treatment of people with depressive episodes.

Contraindications

When should we not prescribe the antidepressant we are considering? What does the instruction say about this? "Melitor" is contraindicated in:

• Increased individual sensitivity to the drug;
• Lactase insufficiency;
• Severe liver disorders;
• Malabsorption of glucose / galactose;
• In old age;
• Congenital intolerance to galactose;
• Pregnancy;
• At a minor age;
• Breastfeeding.

In addition, this remedy is cautiously prescribed to patients with a history of hypomania or mania, impaired renal function, alcoholism (in the event that a person receives hepatotoxic drugs).

Instructions

"Melitor" is intended for oral administration. The tablet is swallowed whole, not crushing and not chewing. It is taken regardless of eating. With the development of side effects on the part of the digestive tract, medication can also be used during the meal.

The daily dose should be taken once a day, before bedtime.

The duration of treatment and the dose of the medicine is determined by the doctor individually.

Usually an adult is prescribed 25 mg of medication per day. With an insufficiently pronounced therapeutic effect, 2 weeks after the start of treatment, the dosage is increased to 50 mg per day.

People receiving this therapy should constantly monitor liver function.

The course duration in patients with depression should not be less than six months.

Adverse events

Is the drug treated well by patients? What does the instruction tell you about this? "Melitor" only in some cases causes the development of side effects. In most people, they go through 2 weeks.

So, against the background of taking this remedy, patients can experience:

• Nausea, gastralgia, stool disorder, increased transaminase levels of the liver and hepatitis;
• Dizziness, migraine, headache, visual impairment, disturbance of wakefulness and sleep, paresthesia, suicidal thoughts, unreasonable sense of anxiety;
• Skin rash, hives, itching, erythematous rash and eczema;
• Myalgia, asthenia, back pain.

An overdose of the drug

What are the symptoms of an overdose of Melitore tablets? The instruction says that at the moment no such messages have been received from patients. When taking the drug in elevated doses, it shows gastric lavage and the reception of enterosorbents. Symptomatic therapy is also performed.

Drug Interactions

The kinetics of the drug in question may change when it is combined with preparations metabolized by the enzymes of the cytochrome CYP 2C9 / 19 and P450 1A2. In particular, it is not recommended to prescribe this medication with "Ciprofloxacin" and "Fluvoxamine".

As for "Propanolol", "Enoxacin", "Grapafloxacin," they should be used with extreme caution for those who are already receiving treatment with Melitour.

Feeding and Pregnancy

Is it possible to take the preparation "Melitor" during the gestation period? The instruction informs, that such means can be appointed or nominated to pregnant women, but only under vital indications. Experiments on animals have revealed that agomelatine does not adversely affect the development of the fetus. Although data on the safety of this drug in pregnant women is not enough.

If the drug is required to be taken during lactation, it is necessary to consult with the treating doctor and decide on the interruption of breastfeeding.

Special recommendations for taking medication

What do you need to know before taking the medication "Melitor" (25 mg)? Instruction, reviews report that this tool is not recommended for elderly patients.

With the development of manic signs treatment should be interrupted.

In some cases, improvement after taking the pill does not occur in the first few weeks. Therefore, the condition of the patient requires constant monitoring. In the early stages of recovery, the development of suicidal thoughts may increase.

All patients taking "Melitor" should always monitor the liver. With an elevated transaminase content in the blood, the test should be repeated for two days. With an increase in the rates of 3 times, therapy is discontinued.

Treatment with the drug should be carried out with extreme caution if the patient has risk factors for liver damage, including obesity, non-alcoholic fatty illness, as well as significant alcohol consumption or simultaneous use of drugs that have hepatotoxic effects.

Analogues and cost

The price of the antidepressant Melitor is 850 rubles. If necessary, this remedy can be replaced with such drugs as "Lotosonik", "Azafen", "Neurol", "Adeptress", "Cetol", "Sevprem", "Zalox", "Trittico", etc.

Patient Reviews

Now you know the properties of such an antidepressant, as "Melitor". Instructions for using this medication have been described above.

Many patients argue that this tool effectively manifests itself in a deep depression. It eliminates depression, reduces lethargy and returns interest to life. However, it should be noted that only an experienced specialist should prescribe this drug. It is he who can determine the safe dosage of the medicine and the duration of treatment.

Also, to the merits of this tool, consumers attribute a low probability of side effects, a small number of contraindications and ease of use (the tablet should be taken once a day).

As for the shortcomings, they only include the high cost of the drug.