"Clozapine": instructions for use, analogues, price

Brain trauma, stress, anxiety, alcohol abuse, drug addiction, genetic predisposition - all these factors can cause schizophrenia and other mental disorders. To correct the situation and cure a person of such serious problems, Clozapine will help. This antipsychotic agent, which should only be used under the supervision and supervision of a doctor. Today we learn all about this medicine: the form of its release, the rules of use, analogues, cost.

When can it be useful?

The preparation "Klozapin", the instruction on which application is placed in the insert, can be written out by the doctor with the following problems:

- schizophrenia in any its stage;

- psychoses;

- sleep disorders;

- Depression;

- psychomotor agitation;

- emotional and behavioral disorder.

Components, form of production, country of manufacture

The main component of the drug is clozapine.

Produced in the form of:

- tablets of 25, 50, 100 mg, the package may contain 10, 50 or 100 pills;

- granules for children (in bags of 500 mg);

- solution for injection (in ampoules of 2 ml).

The medicine is produced in India, Russia, Germany.

Instructions for the use of tablets

The dosage of Clozapine is determined individually. Usually the daily norm is from 200 to 400 g. The first time the doctor appoints 25-50 mg, gradually within 1 or 2 weeks, bringing to the desired dose.

After the main course of therapy, the doctor can prescribe supportive treatment, in which it will be necessary to take from 25 to 200 mg of the drug.

In small daily doses of the drug "Clozapine", instructions for the use of which should always be in the package, are taken at:

- renal, hepatic or heart failure;

- cerebrovascular disorders;

- problems with sleep.

The daily dose should not be more than 600 mg.

Instructions for the use of solution and granules

The drug "Clozapine" can be used for injections. The drug is administered intravenously by a nurse 2 ml each.

For children this medication is prescribed in the form of a solution. To do this, it is necessary to pour the granules from the packet into a glass, pour in 10 ml of water, stir well. For 1 reception you can drink from 5 to 20 mg of the drug, depending on the age of the child. However, the maximum daily allowance for children should not be more than 100 mg of Clozapine solution. A doctor's recipe is a prerequisite when buying this medication in any form of release. Without it, the pharmacist will not sell the medicine.

Contraindications

Tablets "Clozapine" are forbidden to use:

- with a strong susceptibility to the components of the drug;

- during epilepsy;

- with vascular insufficiency;

- during intestinal obstruction;

- with hepatic, renal insufficiency;

- if the patient can not regularly take a blood test;

- during alcoholic psychosis, drug intoxication;

- with granulocytopenia, agranulocytosis;

- with coma;

- women who carry children under the heart, and also during lactation:

- boys and girls under 5 years.

Undesirable effects

The drug "Clozapine", the instruction on its application to which many seem incomprehensible, must be taken with caution. Side effects after treatment with this drug may be different, for example:

- tachycardia, arterial hypertension, respiratory arrest.

- nausea, vomiting, heartburn, abdominal pain;

- increase in body weight;

- drowsiness, dizziness, fatigue, tremor.

- dry mouth, constipation, increased sweating, problems with urination.

- skin rash, dermatitis, pigmentation, urticaria.

Overdose

The agent "Clozapine", analogues of which will be considered below, must be taken strictly according to the doctor's prescription. Otherwise, unpleasant and even dangerous overdose symptoms may occur:

Confusion of consciousness;

- drowsiness;

- delusional condition;

- convulsions;

- a coma;

- problems with vision;

- tachycardia;

- respiratory depression;

- collapse.

If a person took a large amount of money, then he must help. Treatment for overdose will be as follows:

1. Rinse the stomach.

2. Drink activated charcoal.

3. Seek medical attention.

Cost

The drug "Clozapine", the price of which differs depending on the form of release of the drug, the dosage of tablets and solution, the location of the pharmacy, is currently difficult to acquire. Analogues of this remedy are slowly replacing it. After all, they put a decent price, while the drug "Clozapine" is cheaper. So, for 50 tablets you need to give about 200 rubles. If you take pellets for children, they will cost 1000 rubles.

Relationship with other drugs

Many people do not know that it is very cautious to take the drug "Clozapine". Drugs that can be used in parallel with this remedy, but under the close scrutiny of the doctor:

- pills that suppress the central nervous system, - the fact is that with the parallel reception of such funds, the patient may be intensified by the depression of the respiratory center;

- drugs containing in the composition of ethanol;

- drugs that lower blood pressure;

- tablets that cause myelodepression, parallel reception of such drugs may inhibit bone marrow hematopoiesis;

Also, with special care, you need to use the drug "Clozapine" with caffeine because of the possible increase in side effects.

Substitutes

The drug "Clozapine" has analogues, and there are a lot of them. Among the most popular substitutes are such medicines: Genodin, Quetixol, Quetiron, Nantarid, Zalasta, Ziprexa Zidis, Parnasan, Egolansa. Analogues have exactly the same effect as the drug "Clozapine", but the active substances they have different.

The drug "Kvetixol"

This medication is also intended for the treatment of schizophrenia, as well as manic conditions.

The medicine is produced in the form of tablets. The main active substance of this drug is quetiapine.

The medicine is applied only in relation to adult patients. Usually the daily dose for the first 4 days is not more than 300 mg. In the future, the doctor can increase the dosage of this drug to 450 mg per day.

The cost of tablets "Kviteksol" of 25 mg (30 pills) will cost a man of 200 rubles. If you buy tablets in a larger dosage - 100 mg in the same amount, then you have to pay about 750 rubles.

The drug Ziprexa Zidis

This medication can compete well with the medicine in question. Ziprex Zidis is available in the form of tablets, where olanzaline acts as the active ingredient.

Used pills in such cases:

- Treatment of exacerbations of schizophrenia;

- therapy of acute manic conditions;

Treatment of depression.

The daily dose of the drug is determined personally, depending on the diagnosis of the patient.

To treat schizophrenia , the doctor initially prescribes 10 mg of medication once a day.

For the treatment of acute mania, the recommended initial dose is 15 mg 1 time per day.

But these are all conditional values. For a specific regimen for the treatment of the aforementioned ailments, you should consult your doctor.

The medicine "Ziprexa Zidis" is released on prescription.

The cost of 7 tablets is about 2500 rubles. This is very expensive, given that the pills in the package will last only for a week. And for 28 tablets you need to give about 9 thousand rubles.

The medicine is produced in the UK.

What is the register of medicines?

This is a documentation system that contains complete information about medicines. This includes: a registration certificate, instructions for use, an order for the production of a medicine, etc. All new drugs, including the "Klozapin" medication, are included in this register of medicines. This list allows you to officially use a particular tool.

As for the drug "Clozapine", it is issued under several trade names, and in the register they all are prescribed, for example:

- Medication of Ukrainian production "Azalepro".

- The Swiss drug "Leponeks."

- Russian tablets "Klozasten" and "Azaleptin".

Each of these medicines has its state registration number, the end date and the registration renewal.

The name of the drug "Clozapine", the synonyms of which were listed just that, is international. And already medicines such as Azaleprol, Leponex, Klozasten and Azaleptin are considered to be its derivatives. They are developed and implemented in a specific country.

The drug "Azaleptin"

This is also an antipsychotic drug, a neuroleptic, prescribed for schizophrenia, manic states, psychoses, psychomotor agitation, emotional disorders in children, etc.

A drug is produced in the Russian Federation.

The form of the release of the drug "Azaleptin" is the only one, and it is a tablet of 25 and 100 mg. The active substance of the drug is clozapine.

About 420 rubles should be given for 50 tablets of 25 mg of "Azaleptin". "Klozapin" - a medicine to which the article is devoted, costs two times cheaper.

Swiss drug "Leponeks"

This is another synonym for the drug under consideration, which is prescribed for the same health problems. The medicine "Leponex" is produced in two forms:

1. Pills.
2. Injection.

As the active substance of this drug is the same clozapine. One Leponex tablet can contain 25 or 100 mg of the main component. And additional elements are: magnesium stearate, anhydrous silica gel, talc, corn starch, polyvinylpyrolidone, lactose.

At the initial stage of treatment on the first day, 1 tablet (25 mg) is prescribed 1 or 2 times a day. On the second day - 2 pills. In the future, the doctor can gradually increase the dose to a maximum of 300 mg.

The drug "Leponex" also has the same side problems, limitations in the application as the drug in question.

The cost of these 25 mg tablets in the amount of 50 pieces is 1200 rubles. And for 100 pills of 100 mg will need to give 5400 rubles. This is much more expensive than the means of "Klozapin", the price of which will be affordable for any person. It turns out that the medicine "Leponeks" for some categories of the population (low-income people) will be inaccessible.

Conclusion

From this article, you learned a lot of interesting and useful information about the drug "Klozapin." Instructions for use, contraindications, side effects, cost have been described. We realized that this medicine has many analogues that can compete with it. True, the cost of these drugs is higher. However, in pharmacies, these analogues have long ago supplanted the drug "Clozapine." But if you are lucky enough to find him, then you will save a lot.