"Arthrosan": instructions for use

"Arthrosan" instruction on the application refers to the clinical and pharmacological category of oxycam. The main active substance of the drug is meloxicam, which is an effective selective inhibitor of COX-2. Under the name "Meloksikam" this medicine is registered in the INN registry.

In tablet form, the drug is produced in the form of tablets weighing 7.5 or 15 mg, packed in cellular contour blisters.

According to its pharmacological properties, the drug "Meloksikam", which is a derivative of enolic acid, acts as an anti-inflammatory and analgesic agent. This mechanism is based on the ability of the drug to inhibit the synthesis of prostaglandins. Under the influence of the drug, a reaction occurs, during which the activity of the enzymes COX-2 that selectively inhibit the main participation in biosynthesis is inhibited.

When taking the drug "Arthrosan" the instruction explains its effect in this way. If the drug is prescribed in large doses, then during a long period of its use there is a decrease in selectivity for COX-2. The drug has less effect on COX-1, which provides protection for the gastrointestinal tract. That's due to this selective action and protects the digestive tract from erosive and ulcerative lesions.

Anti-inflammatory effect of the drug "Arthrosan" instructions for use connects with the suppression of the activity of the enzyme COX-2, which acts in the area of the inflammatory process.

The pharmacokinetics of Meloxicam are characterized as follows. Distribution: "Arthrosan" is able to overcome in the body histogematic barriers, due to this the connection with plasma proteins reaches 99%. In the synovial fluid, the concentration is 50%.

Metabolism: The drug is almost completely metabolized in the liver cells, with the formation of several neutral derivatives with pharmacological properties.

Excretion: The drug "Meloksikam" is excreted approximately in equal parts mainly with urine and feces in the form of metabolic products. Only 5% of the components are excreted through the intestine.

Pharmacokinetic properties of the drug "Arthrosan" instructions for use also determines for special cases. In particular, in elderly patients with admission, the clearance of the drug decreases, and in cases of symptoms of hepatic as well as renal insufficiency, the drug has little effect on pharmacokinetics.

The drug "Meloksikam" is fairly well absorbed from the digestive tract, while its bioavailability level reaches 89% and does not change from eating. Reception in the produced doses provides a proportional dose of the concentration of the drug in the body.

Distribution: As a rule, the optimal Css values come on the third or fifth day of the drug intake, and with its long-term use stable concentrations comparable with the initial pharmacokinetic parameters are provided.

The dosage of the preparation "Arthrosan" is specified in the instructions for use as follows.

Use the drug is recommended in a combined form. Recommended scheme:

- in the initial stage of treatment, for 2-3 days, apply "Artrozan" -schools;

- after three to four days of intramuscular injection, the drug should be taken orally - in the form of tablets.

The dose for both intramuscular and oral administration is the same, and is equal to the standard (7.5 or 15 mg) once during the day. The dose and duration of application are determined by the intensity of pain and the severity of the inflammation. When determining the dose, careful consideration should be given to the potential risk of complications from the gastrointestinal tract.

In the presence of renal failure, the daily maximum dose is not more than 7.5 mg.

Interaction with other drugs can be complicated by the occurrence of erosive-ulcerative phenomena in the digestive tract. Do not take the drug during pregnancy and breastfeeding.

The drug "Meloksikam" should be stored in a dark place for no more than two years.

The drug is sold only on prescription.