"Akineton" preparation: instructions for use, description, reviews

Active substance "Akinetone" is biperiden hydrochloride. The tablet contains 2 mg of active ingredient. In addition, the presence of additional components (corn starch, potato starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, copovidone, calcium hydrogen phosphate dihydrate, talc, pure water) presupposes the formulation of the drug "Akinetton".

Instructions for use, photos suggest that the tablet form of the preparation has a practically white color, a flat-cylindrical shape. On one side of the tablet there is a risk with cross-shaped facets.

1 ml of the solution contains biperiden lactate in an amount of 5 milligrams. Additional components are: injection water and sodium lactate.

pharmachologic effect

The main substance of biperiden is central anticholinergic.

The effect presupposes a depressant effect on the activity of cholinergic neurons in the striatum, which is the structural unit of the extrapyramidal system.

The drug causes ganglion blocking effect, spasmolytic and moderate expression m-cholinoblocking effect on the periphery (spasmolytic).

The use of the drug helps to eliminate tremor of the extremities, which occurs when using cholinergic drugs (eg pilocarpine), as well as catalepsy and muscle rigidity with the use of neuroleptics. Has the ability to provoke psychomotor agitation.

Pharmacokinetics

" Akineton" binds to plasma proteins by 91-94%. The plasma clearance will be 11.6 ± 0.8 ml / min / kg of body weight. A single oral administration has a bioavailability of about 33 ± 5%.

Capable of penetrating into breast milk.

Biperiden is fully metabolized in the human body. In urine, in unchanged form, this substance is not determined. The main metabolites are bicycloheptane and piperidine, which are excreted with feces and urine.

Elimination is carried out in two phases, with a half-life (T 1/2) of 90 minutes during the first phase and 24 hours of the second phase. In elderly patients, the half-life can increase significantly.

Indications for use

"Akineton" is used for extrapyramidal disorders caused by taking certain medications (neuroleptics, antipsychotics).

Also, the drug is indicated in the diagnosis of Parkinson's disease, Parkinson's syndrome (the drug is prescribed in combination with basic therapy),

Contraindications

The purpose of this drug is not indicated for individual intolerance of the active substance of the drug "Akineton."

Instruction for use informs that the prescription of the drug should be avoided when diagnosing a patient such pathology as prostate enlargement, angle-closure glaucoma, obstructive changes in the gastrointestinal tract (stenosis of the pylorus, intestinal obstruction of paralytic genesis).

Arrhythmias, epilepsy, breastfeeding, the elderly patient, pregnancy are factors in which "Akineton" is appointed with great care.

Side effects

From the side of the central nervous system are asthenia, increased fatigue, drowsiness weakness, numbness, dizziness, a sense of concern, anxiety, memory impairment, confusion, hallucinations, catalepsy, drug dependence on the drug "Akineton."

Instructions for use indicate side effects from the side of the eye - mydriasis, a violation of accommodation.

From the side of the cardiovascular system is characterized by an increase in heart rate (tachycardia); Sometimes - bradycardia; When using the injection form of the drug - a decrease in blood pressure (hypotension).

On the part of the digestive system - dry mouth, dyspeptic manifestations, constipation.

From the side of metabolic processes - a decrease in sweating.

From the side of the urinary system - in patients with an increase (hypertrophy) of the prostate gland - a possible difficulty urinating.

Allergic manifestations: a rash on the skin, itching.

Methods of application

For intramuscular, intravenous administration, as well as oral administration of the tablet form, the drug "Akineton" is suitable.

Instructions for use suggest that therapy with "Akineton" usually starts with small doses, then the dose of the drug increases stepwise depending on the required therapeutic effect and the presence of side effects.

Adults when using the oral form of the drug begin treatment with a dose of 1 mg in 1-2 doses during the day or 2 mg divided into two doses per day. Further, the dosage can be increased to 8 mg in two to four doses. However, do not increase the dose by more than 2 mg per day. Do not exceed the maximum dosage of the drug at 6 to 16 mg per day. A single dose of the injectable form of the drug should not exceed 2.5-5 mg. This dose can be re-entered in half an hour, but the number of administrations per day should not exceed 4 times. The maximum dose of the drug in the injection form is 20 mg per day. When the optimal dose of the drug is achieved, it is possible to switch to the reception of "Akineton retard."

However, do not forget about the individual approach to each individual patient when prescribing biperiden therapy.

Extrapyramidal pathology resulting from the administration of certain medications (antipsychotics or antipsychotics) requires the administration of this substance in a single dose of 2 mg orally or parenterally. Repeat the administration of this dose can be every half hour. However, as mentioned above, the number of introductions should not exceed 4 times. The oral dose of the drug should be divided into one or three doses.

Parkinson's disease Prescribes the administration of this drug to 6-8 mg orally in 2-4 doses per day, gradually the dose can be increased to 6-16 mg.

A child's age of up to a year suggests the possibility of prescribing this drug in an injectable form slowly, a single dose of 1 mg or 0.2 ml. At the age from a year till 6th years appoint 2 mg or 0,4 ml. From 6 to 10 years - 3 mg or 0.6 ml. This dose can be re-entered after an urgent need in half an hour. If there are side effects on the drug, stop the injection.
When the oral form of the drug is administered in the age of 3 to 15 years, take a dosage of 1-2 mg in 1-3 hours during the day.

Tablets can not be consumed on an empty stomach, and should be washed down with a moderate amount of water. If undesirable side effects occur on the part of the digestive system, the drug should be taken immediately after a meal, which reduces the severity of the adverse effect of the drug "Akineton".

The instructions for use indicate that in the case of nicotine poisoning in adults in the standard therapy complex, this medication is also prescribed, and the dose is 5-10 mg for injection forms, but only in cases that threaten the patient's life.

When poisoning with organic phosphoric mixtures, biperiden dosing is done individually, depending on the severity of the lesion. Start with a dose of 5 mg in the case of intravenous administration, repeated administration continues until the symptoms of poisoning disappear.

Overdose

The overdose is manifested by pronounced anticholinergic effects caused by the drug "Akineton".

Instructions for use, reviews of doctors pay attention to the fact that therapy of this condition is asymptomatic (maintenance of cardiovascular and respiratory systems, oxygen therapy, correction of hyperthermia, if necessary, install a urinary catheter). It is necessary to administer cholinesterase inhibitors (primarily physostigmine) .

Interaction

" Akineton" with simultaneous use with m-holinoblokatorami, drugs that have antihistamine and antiepileptic actions increases the severity of the latter. However, simultaneous use with metoclopramide weakens its therapeutic effect. The categorical incompatibility of the drug with ethanol is noted. The appointment of quinidine increases at times the risk of developing manifestations of dyskinesia. M-cholinergic effect is enhanced with levodopa.

Storage and sale conditions

To purchase this drug, you need a doctor's prescription to provide the pharmacist. To store the "Akinetton" you need to comply with the temperature regime, ie, the ambient temperature should not exceed a value of 25 degrees (Celsius scale). Requires inaccessibility for children to the drug "Akineton".

The instruction gives a shelf life of the drug - five years.

special instructions

The appointment of biperidene during pregnancy and breastfeeding (lactation) requires the presence of strict indications.

Biperiden can enter the body of a baby with breast milk, which is the reason for the temporary abandonment of breastfeeding before the abolition of the drug "Akineton".

Description of the drug draws attention to the fact that when deciding on the appointment of biperidene during pregnancy and lactation, consider the possible risk to the newborn, the fetus.

The patient's elderly age becomes a risk factor in the treatment with this drug. Therefore, designate "Akineton" of this category of persons with great caution.

The lack of any data indicating safety of use in childhood is the reason why the drug "Akineton" is not used for children.

Description of the drug (instructions for use) indicates the fact that caution is required when using this medication in patients with epilepsy or arrhythmia.

With prolonged use, drug dependence may develop.

The risk of developing the withdrawal syndrome involves the gradual cessation of therapy with "Akinetton."

During the period of therapy should avoid the use of alcohol-containing beverages.

Therapy with this drug presupposes the need for abstinence from driving by vehicles and occupations that require high concentration of attention and a rapid psychomotor reaction, as this carries a potential danger due to the risk of dizziness.

"Akineton." Instructions for use. Analogues

Synonyms for the drug are the following substances: "Biperiden", "Mendileks", "Biperidena hydrochloride."

"Akineton." Reviews

The drug has a high effectiveness in the treatment of parkinsonism, tremor in the limb is terminated after a short period of time. There is a good tolerability of the drug "Akineton".

Reviews on the forums talk about the possibility of some side effects during the period of taking the medicine.

The price of "Akinetton". Where can I buy

The cost of the solution can be about 800 rubles.

The price of the oral form of "Akinetton" is 560-580 rubles.