Instructions for use, analog "Cefotaxime" and reviews

"Cefotaxime" (indications for use, rules for calculating the optimal dosage, as well as the most popular analogues will be given below) is a modern semisynthetic antibiotic. It is resistant to beta-lactamases and is active against both gram-positive and gram-negative microflora. The mechanism of the biochemical reaction is due to the ability of the components to suppress natural processes occurring in the cell membrane of pathogens.

The drug, getting into the body, purposefully destroys the cruciform couplings of peptidoglycans, so necessary for bacteria to ensure the natural stability of the walls. And, as is known, for the antibodies and ingredient-inhibitors, the elastic cell-aggressor is a fairly easy target.

Form of issue

The drug "Cefotaxime" (the injection and infusion instruction presents as the only possible delivery scheme for the active substance) enters the pharmaceutical market in the form of white or yellow powder, which serves as the basis for the preparation of the solution. It is about the so-called injection ampoules.

Original bottles with a volume of 10 ml are made of transparent glass. The actual mass of the reagent present in one commodity unit depends on the packing matrix (0.5, 1.0 or 2.0 grams).

Pharmacokinetic scenario

It should be noted immediately that not every analog of "Cefotaxime" has the same pharmacokinetic properties as the original. In particular, if we talk about the speed of absorption of components from the injection site, then the assimilation of the described drug, judging by the comments of many practitioners, occurs much faster than the primary absorption of the same "Duatax" or "Cetax". The reason for the "phenomenon" lies in the structured molecule of the original sample. Experts in their reviews emphasize that the above Indian generics contain "pharmaceutical impurities" in the form of complex cephalosporin derivatives, which significantly slow the metabolism of other ingredients.

It has been established that "Cefotaxime" (indications fixed in the official guide to this drug, exclude the possibility of appointment in the presence of bleeding) demonstrates a relatively high level of binding to plasma proteins, while the duration of the bactericidal effect varies within 11-12 hours. After the initial transformation, the reagent is evenly distributed among the tissues, including bone (the maximum concentration is also observed in the myocardium and gall bladder).

The main ingredient successfully overcomes the placental barrier and becomes an integral part of the pericardial and cerebrospinal fluid. On average, the half-life with intravenous drip infusion does not exceed one hour, with intramuscular injection - eighty-one hundred minutes. There is no any other form of accumulation of substance - some of the components are excreted together with bile, the other (about 90%) - with urine. In the latter case, the share of active metabolites is limited to 20-30% of the administered dose, that is, about 70% of the solution leaves the body without undergoing structural modifications.

Indications for use

The described drug has well established itself as a blocker of infectious inflammatory processes, triggered by microorganisms particularly sensitive to cefotaxime. And this is evidenced not only by clinical studies - a similar conclusion can be drawn after reading the numerous positive reviews published on the sites, the subject of which is the effective drug control of pathogens. The front of the pharmacological effect of this drug is quite wide, but most often "under sight" are chronic or acute disorders of the kidneys and urinary tract, as well as ENT diseases.

I must say that, even with an absolute identity of the composition, the analog of "Cefotaxime", whether "Tsefasin" or "Cetax", can not be assigned to use on the basis of the above conditions. The fact is that many generics are characterized only by the "relative copying" of the biochemical model of the behavior of the original sample, and therefore an accurate medical expert should calculate the exact medication card taking into account the schedule of taking and dosage of the "double".

The original product is recommended for use if:

• The patient is diagnosed with the pathology of the respiratory system in the form of pneumonia, abscess or bronchitis, and other antibiotics do not bring the desired result;
• The patient's condition is aggravated with progressive bacterial meningitis;
• Analyzes confirmed the presence of endocarditis;
• In the postoperative period, it was not possible to avoid complications in the form of focal destruction of the skin and / or shell of vital organs;
• The pathogens of infection are firmly established in bone tissues, and intramuscular injections with the use of drugs-synonyms do not exert a proper influence on them;
• Gram-negative or gram-positive flora penetrated into burn wounds and provoked large-scale infections (up to sepsis);
• There was a need for preventive measures.

Independent experts are inclined to believe that today there is little analog of "Cefotaxim" capable of demonstrating a clearly expressed positive dynamics in Lyme disease. It is worth recalling that the described original, subject to regular application, with the task in hand copes perfectly (comments on the nuances of the therapeutic course, patients post on the forums).

Application and dosage

"Cefotaxime" instruction (injections, according to some doctors and patients, are not as effective as setting up a dropper) is positioned as an antibiotic of selective action, aimed at combating severe bacterial infections. As it was already said, there are three schemes for the delivery of the reagent: by drip or jet infusion, as well as by intramuscular injection. A single rule for the preparation of working fluid does not exist, therefore it is extremely important to determine in advance the method of administration of the preparation.

The manufacturer, in particular, recommends adhering to this algorithm:

• For intravenous injections: 1 gram of powder should be dissolved in 4 milliliters of water, lidocaine or novocaine;
• For intravenous injections: 1 gram of the substance should be diluted in sterile water (4 ml);
• For IV infusion: in a bottle with two grams of cefotaxime, add 100 ml of NaCl (0.9%) or the same amount of 5% glucose.

Reagent delivery time:

• With the / m injections: 5-10 s;
• With iv injection: 3-5 min;
• When setting up a dropper: 50-60 min.

Calculation of a balanced dose and the construction of an optimal schedule of reception is carried out individually. The age of the patient and the weight of his body, as well as the type of infection and the stage of its development are taken into account. In addition, therapeutic adjustments are made for the anamnesis.

Nevertheless, the manual still provides information on the weighted average application rates of the drug "Cefotaxime". The injections (how to dilute the powder, described in detail above, but, interestingly, almost all reviews are dominated by the idea that the injection is a very painful and unpleasant procedure, even if all the manufacturer's recommendations are followed), in particular, prescribed in uncomplicated situations, with A break of 4-12 hours and a single dose of 1-2 grams. For critical and precritical scenarios, topical IV administration (based on 2 g every 4 hours but not more than 12 g / day) is relevant.

Pediatricians, when choosing a treatment regimen, are guided by the body weight of the young patient and the general reaction of the body ("standard" - from two to six jet injections, 50-180 mg / kg).

Side effects

With the appointment of the drug "Cefotaxime" (injections reviews are not so flattering as drip infusion, since the / m introduction is often accompanied by a pain syndrome, for this reason the role of "solvent" is usually novocaine or lidocaine), it is impossible to exclude the atypical effect of components on systems And the patient's organs.

Acceptable:

• Allergic "responses" in the form of large-scale hives, candidiasis or edema Quincke;
• Problems at the level of the gastrointestinal tract (vomiting, nausea, extremely rarely - cholestatic jaundice);
• Disorders in the composition of blood (a drop in the level of platelets, hemolytic anemia, etc.).

Consequences of an overdose

Excessive increase in the daily rate is fraught with dysbiosis and encephalopathy; Visualization of skin irritations is also likely.

The primary task is to stop the reagent from entering the body. Further, measures are needed to stabilize the condition with the mandatory use of desensitizing pharmacological products (under the supervision of a physician).

Contraindications declared by the manufacturer

According to the information given in the official instruction, "Cefotaxime" (injections to children, as a rule, are prescribed after reaching the age of 30 months, before resorting to IV infusions) should not be used:

• During pregnancy;
• With increased sensitivity to ingredients;
• With open and closed bleeding;
• If there are already episodes of enterocolitis in the anamnesis.

Drug Interactions

In the original manual, attention is drawn to the fact that other solutions under no circumstances should be introduced together (from one medical device) with the antibiotic "Cefotaxime".

The injections (application through the dropper, in terms of pharmacological interaction with components of other drugs, does not differ from the / m injections), in particular, can provoke kidney damage if an aminoglycoside or loop diuretic acts as an ally of the described drug. In turn, the tubular secretion blockers strongly inhibit the withdrawal of this reagent and stimulate an increase in its concentration.

Combination with antiplatelet agents is also undesirable because of the risk of bleeding.

Special Instructions

"Cefotaxime" (tableted analogues, judging by the responses and comments, are less effective) sometimes provokes false Cumbous assays and "falsifies" urine analysis for the true glucose content.

With prolonged therapy, the component composition of the blood should be measured at least once every 10 days.

In the first days of treatment, a severe form of diarrhea is not excluded. And, what is characteristic, such an analog of "Cefotaxim" (for children under the age of 12 referred to "duplicate" is not recommended), like "Fagotsef", a similar clinical picture is much less likely.

The use of alcohol during therapy on the basis of this reagent is strictly prohibited.

Which analogue of "Cefotaxim" is recommended for use by independent experts?

Comments on "Sefotake" and "Cephanthrae" as synonymous with the described pharmacological product are ambiguous. Judging by the reviews, their appointment by doctors is practiced much more often than prescribing prescriptions for the purchase of the same "Cefabol" or "Tax-of-Bid". However, some patients tend to believe that the therapeutic effect of the use of these samples is poorly expressed, and the likelihood of developing atypical reactions is incommensurably high.

When on the forums the question of how to prick "Cefotaxime" is raised, so that it does not hurt, many doctors advise:

• To check if the discomfort is a reaction to a particular ingredient (if the syndrome repeats and when the powder is diluted with novocaine, then there is reason to believe that the unpleasant sensations are a consequence of allergy, and not direct action of the substance);
• Look for a worthy alternative.

An analysis of opinions shows that the greatest "respect" among the synonyms was awarded to "Loraksim". However, before replacing one reagent with another, it is essential to consult with a specialist.