The drug "Klopixol-Acuffase": instructions for use and reviews

Treatment of mental illness in many people is associated with the use of potent drugs that cause irreparable damage to the nervous system. Therefore, some patients with mildly expressed symptoms prefer to hide them or to fight them independently. This approach is very dangerous and fraught with the development of serious complications. Timely appeal for help to a psychiatrist and the selection of an individual treatment regimen by suitable means is a guarantee of maintaining a normal way of life in the future.

Mechanism of action

"Klopiksol-Akufaz" is a medicinal solution for intramuscular injection. It refers to neuroleptics, that is, drugs that are used to treat various diseases of the psyche. The active substance in the solution is zincopentixol acetate.

Psychotic reactions can develop due to disruptions in the work of neurotransmitters (most often dopamine and serotonin). Normally, these compounds provide the transfer of the nerve impulse to the receptor termini. To reduce their activity and restore the brain's ability to objectively think, neuroleptics are used. Zuclopentixol blocks dopamine receptors, due to which it exhibits antipsychotic action.

The substance also inhibits the transfer of impulses in the nerve endings of the brain stem, has a calming and relaxing effect. It reduces the gag reflex, so it can be used in situations in which hysterics is accompanied by nausea and a headache.

Indications

"Klopiksol-Akufaz" is used to treat the initial stages of acute mental illnesses, exacerbations of chronic psychoses and to reduce the manifestation of manifestations of manic obsessions. In combination with other components of the treatment, this remedy returns a person to the real world. It effectively eliminates the following signs of a beginning psychosis:

• Nervousness and unmotivated aggression towards others;
• Lack of interest in life, apathy;
• Memory impairment;
• Decreased mental performance;
• Anxiety and causeless fear;
• Indifference to their appearance, a constant disregard for the elementary rules of hygiene;
• Isolation and reluctance to communicate with people;
• Excessive suspicion and mistrust.

The maximum concentration of the drug in the blood is noted on day 3 of treatment, although the sedative effect develops much earlier (approximately 15 minutes after intramuscular injection).

Clopixol-Acuffase: instructions for use

The solution contains 50 mg of zincopentixol acetate in 1 ml. Depending on the patient's illness, the dose of the medicine is selected individually by the attending physician. The recommended initial amount of the drug is 1-3 ml intramuscularly. One injection is enough to maintain a stable concentration of active substance in the blood for several days. The number of injections and the interval between them can be adjusted by the attending psychiatrist, given the tolerability of the remedy and the severity of its action.

In the treatment of the elderly, many antipsychotics are undesirable to be administered at the maximum allowable doses. This applies to the drugs "Klopiksol-Akufaz". Instructions for using the drug involves reducing the amount of the injected solution to 1-2 ml once. Exceed these values is highly not recommended in order to avoid the development of side effects and allergic reactions.

Contraindications

Any antipsychotics can not be used in certain concomitant pathological conditions. This should be taken into account when prescribing the drug "Clopixol-Acuffase". Contraindications for its use are as follows:

• Cardiovascular failure (collapse);
• Pheochromocytoma;
• coma;
• The state of drug or alcohol poisoning.

The drug is not used to treat pregnant women, especially in the first trimester, when the laying of all organs and systems of the future baby. During lactation, the administration of this medication is also undesirable, although it is excreted in milk as little as possible. If there is an acute need to combine medical therapy with breastfeeding, it is possible. In this situation, it is necessary for the newborn to have a permanent pediatric observation in order to react in time if the drug has a negative effect on the child.

Side effect

Undesirable effects on the background of treatment are rare. This usually happens when the solution is used for a long time in large quantities. As a rule, with a decrease in the dose, they pass, although sometimes it is necessary to replace Clopixol-Acuffase with alternative agents. Side effects can be expressed by such systems and bodies:

• Nervous system (motor disorders, pathologies of accommodation, increased fatigue and a constant desire to sleep);
• Cardiovascular system (dizziness and pressure decrease with a sharp change in body position, rapid pulse);
• Digestive organs (fluctuations in the level of liver tests, insufficient salivation, violation of defecation);
• Excretory system (impossibility of emptying the bladder).

Since the drug has a bright sedative effect, during the course of treatment the patient is undesirable to drive a car and work with precise mechanisms that require concentration of attention.

Rules of admission

"Clopixol-Acuffase" refers to non-toxic medicines, which are mostly easily tolerated by patients. However, given that the product is available as an oily solution, it can be administered exclusively intramuscularly. Intravenous injections can lead to a fat embolism, which is very dangerous for human life. It is fraught with clogging of the main blood vessels and stopping breathing.

Even with a noticeable improvement and a visible absence of symptoms, you can not abruptly stop using Clopixol-Acuffase. Annotation to the tool assumes in such cases the selection of maintenance therapy or switching to tablets with the same active substance. It is very important to adhere to all the recommendations of the attending physician, because the unauthorized cancellation of the drug almost always leads to a new exacerbation and, as a result, to severe psychological problems.

Compatibility with other medicines and alcohol

Virtually all drugs used in psychiatry are incompatible with alcohol (including Clopixol-Acuffaz). Treatment with this drug provides for the refusal of alcohol and any narcotic substances, because when combined in the body they are very depressing the work of the brain and the entire nervous system. The drug also enhances and prolongs the effect of medications for general anesthesia.

A combination of a drug with antiemetic drugs (for example, "Cerukal") and anthelmintic ("Piperazine") is considered dangerous. The risk of developing extrapyramidal pathology in this case increases much more than with the separate use of these funds.

The Clopixol-Acuffase solution (analogues of the remedy including) is not prescribed together with guanethidine and similar means for the treatment of hypertension. In Parkinson's disease, the use of this antipsychotic is contraindicated, since it does not combine with the usual therapy for such patients.

How to switch to other dosage forms?

To maintain the antipsychotic effect, a psychiatrist can choose an individual scheme for switching to a more convenient dosage form. Most often, the patient is recommended to replace injections with a conventional solution with a deposited option. Usually, one injection of this medicine is sufficient once every 2 weeks to achieve the desired concentration of the agent in the body tissues.

This regime does not affect the normal way of life, and in the absence of direct indications for hospitalization, a person can continue treatment at home. Less often, instead of injections, tablets are prescribed, the dose of which is calculated individually, based on the characteristics of the patient's organism and the severity of the disease.

The advantages and disadvantages of the drug

"Clopixol-Acuffase" is available in a convenient dosage, which allows you to reduce the number of injections to a minimum and, thus, do not focus on this patient's attention. Unlike other neuroleptics, in the treatment of psychosis, a course of 2-4 injections of this medication is sufficient to achieve a lasting effect. With a properly selected dosage, the drug avoids the parallel use of tranquilizers. Treatment with the drug helps to eliminate not only the signs of psychosis, but also some symptoms of schizophrenia (propensity to isolation, emotional exhaustion).

A relative disadvantage of the drug can be called its dosage form. Since the drug is released in solution, it can only be injected. This requires the help of medical staff and the observance of sterility. However, given the efficacy and wide spectrum of the drug "Clopixol-Acuffase" (indications and clinical data confirm this), these nuances are not particularly significant.

Patient Reviews

Mentally ill people deserve attention and support not less than those who are physically ill. Not understanding the danger of illness during an exacerbation, they can harm themselves or others. Therefore, those who encountered such a problem during the period of "enlightenment" are ready to try any methods of treatment and drugs in order to normalize their thinking and reaction to the world around them. One of the most effective drugs available in this case is Klopiksol-Akufaz. Reviews of the drug confirm the fact that the relief from psychosis patients was very rapid, and then a prolonged remission was observed.

Few patients complained of side effects, and mostly they were associated with high dosages of the drug administered. People noticed that during treatment the desire to hide from relatives and not communicate with medical personnel gradually left them. Over time, they could normally socialize in the usual circle of communication and retain critical thinking.

Reviews of doctors

During treatment with neuroleptics, a sedative effect is often accompanied by a significant decrease in pressure (this also applies to Clopixol-Acuffase). The instruction warns about this, although in practice doctors note that most often pronounced hypotension with the use of this drug is not observed.

Psychiatrists describe a rapid sedative effect in psychoses, schizophrenia and manic states. Unfortunately, the medicine does not lead to improvements in cognitive and analytical abilities of the brain, which are disrupted in schizophrenia. The drug is not peculiar. For these purposes, patients should be individually assigned additional funds.

The medicine is used to treat elderly people. It eliminates anxiety and relieves the symptoms of mental agitation. In people with Alzheimer's disease, it helps to remove aggressiveness and improves sleep, but this does not happen as quickly as in patients with vascular pathologies.