Means of "Plakvenil". Instructions for use

The drug "Plakvenil" is used for rheumatoid, juvenile arthritis, discoid, systemic lupus. In practice, the medication was also prescribed for the prevention and treatment of malarial seizures.

Dosing regimen

The drug "Plakvenil" for children is prescribed per kilogram of 6.5 mg. At the weight of the child up to 31 kg, the total amount of the medicine should not be more than two hundred milligrams. Adults, the elderly including patients with rheumatoid arthritis are recommended per kilogram of 6.5 mg. The maximum permissible dose per day is not more than 400 mg. It is recommended that the product be washed with milk in sufficient (not less than 200 ml) volume. In the treatment of arthritis, the medication "Plakvenil" (instructions for use contains such information) may be taken in conjunction with glucocorticosteroids, salicylates. The dosage of these and other additional agents can be reduced. So, the medication "Cortisone" is taken in an amount of 5-15 mg less, "Hydrocortisone" - less by 5-10 mg, "Methylprednisolone" or "Triamuinolone" - 1-2 milligrams less, "Prednisolone" - less for 1- 2 mg, "Dexamethasone" - by 0.3-0.5 mg. In the treatment of lupus erythematosus means "Plakvenil" instruction for use recommends 400 mg / day. The frequency of medication is 1-2 r. To prevent the manifestation of malarial seizures, the drug is taken two weeks before the expected trip to the epidemiological areas. If there is no possibility to begin therapy at this time, a double loading dosage is prescribed - 800 mg for an adult. For children, the "Plakvenil" preparation (instruction for use confirms this) is given in an amount of 12.9 mg per kg. The daily dose is taken twice at an interval of six hours. After leaving the field of epidemiological danger, prevention is carried out for another two months. When an acute malarial attack occurs, the adult is given 800 mg, after six to eight hours, another 400 mg, over the next two days another 400 mg. For children, the dose is 32 mg per kg. Means "Plakvenil" instruction for use at the same time recommends drinking for three days.

Side effects

On the basis of therapy or prevention, myopathy, headache, neuromyopathy, convulsions, psychosis are likely. The agent "Plakvenil" (the instruction on application on it specifies) can cause accommodation disorder, hearing loss, anemia of hemolytic or aplastic type, keratopathy. The negative consequences of prevention or treatment include tinnitus, soreness in the abdomen, upset of the liver, atrophy in the optic nerve, pigmentation disorder. In some patients there was hypertrophy of the myocardium, atrioventricular blockade, emotional lability. With an increase in the dose of the drug "Plakvenil" (instructions for use warns about this), side effects are intensified. Overdose in children increases the risk of death. When poisoning with the drug is recommended urgent gastric lavage, symptomatic therapy. Assign activated charcoal, ammonium chloride.