"Kondronova": instructions for use, description of the drug, feedback

Osteoarthrosis is called degenerative-dystrophic joint disease. Its cause is the development of damage to cartilaginous tissues located on articular surfaces. Such a pathological condition can arise from trauma, dysplasia and inflammation.

Quite often this disease is inherited. It also develops due to excessive body weight, in old age and due to a specific profession.

To restore cartilaginous tissues on articular surfaces, doctors prescribe to patients special preparations. One of them is the medication Kondronova. The price of this medication will be presented later. Also in the materials of this article you will find instructions on the use of this drug, its properties, analogs, form of release and contraindications.

Composition, shape and packaging

In what form are the medicines manufactured by Kondronov? Reviews of consumers say that this medicine is available in capsules. They are placed in blisters or contained in jars of PVC (placed in cardboard bundles).

What substances does the "Kondronova" preparation contain? Tablets have the following active ingredients: glucosamine sulfate and chondroitin sulfate.

Also it should be said that the composition of the drug in question includes auxiliary ingredients in the form of mannitol, magnesium stearate, croscarmellose sodium and purified talc.

The capsule shell consists of water, gelatin, sodium lauryl sulfate, povidone, bronopol, titanium dioxide dye, a brilliant blue dye and quinoline yellow dye.

Mechanism of action

What are the Kondronov capsules? Instruction for use reports that this is a tool that stimulates the regeneration of cartilaginous tissues. Its effectiveness is due to the components that make up the composition.

Chondroitin and glucosamine sulfate are involved in the synthesis of connective tissues, and also contribute to the prevention of cartilage destruction processes and stimulate regeneration.

The use of exogenous glucosamine improves the production of the cartilage matrix, providing it with non-specific protection against possible chemical damage.

Glucosamine in the form of a sulfate salt is a precursor of hexosamine. As for the sulfate anion, it is required for the synthesis of glycosaminoglycans.

It should also be noted that another function of glucosamine is to protect the damaged cartilage from metabolic damage, which is caused by the intake of GCS and NSAIDs. In addition, this substance has a moderate anti-inflammatory effect.

What other properties does the Kondronov medicine have? Capsules containing chondroitin sulfate serve as an additional means for the formation of healthy cartilage. This fact does not depend on whether the drug is absorbed in intact form or as separate elements.

It should also be said that this substance can stimulate the formation of hyaluronone, type II collagen and the synthesis of proteoglycans, and also protect hyaluronone from enzymatic degradation (by suppressing the activity of hyaluronidase) and the damaging effect of free radicals.

According to experts' reviews, chondroitin sulfate not only maintains the viscosity of the fluid synovial, but also stimulates mechanisms of cartilage repair, suppressing the activity of those components that split it (for example, elastases or hyaluronidases).

So what is remarkable about the Kondronov medication? The reviews state that when treating osteoarthritis, it significantly alleviates the symptoms of the disease and reduces the need for patients to take NSAIDs.

Kinetics of the drug

Let us consider the kinetic properties of each component in more detail.

• Glucosamine.

The biological availability of this substance when administered orally is 25%.

It is distributed in tissues. Maximum concentrations of the element are found in articular cartilage, liver and kidneys. Approximately 30% of the dose taken persists for a long time in the muscle and bone tissues.

Glucosamine is excreted along with urine and feces for 68 hours.

• Chondroitin sulfate.

Taking this element inside at a dosage of 800 mg promotes an increase in its concentration in the blood during the day. Absolute bioavailability is 12%. Approximately 10% and 20% of the dose taken is absorbed in the form of high molecular weight metabolites and low molecular weight derivatives.

Chondroitin sulfate is excreted in the urine for 5 hours.

Indications

What diseases are prescribed capsules "Kondronova"? Instructions for use indicate that this agent is actively used for the therapy of osteoarthritis in stages 1-3.

Contraindications

When should you not take Kondronova tablets, the analogues of which are listed below? According to the instruction, contraindications to the use of this medication are the following:

• The presence of hypersensitivity;
• Period of pregnancy;
• Phenylketonuria;
• Time of breastfeeding;
• Underage age.

Capsules "Kondronova": instructions for use

On how to take the medication in question, the patient should be told by the attending doctor. Only an experienced specialist, relying on analysis data and general information from a medical examination, will be able to select the right therapy regimen and prescribe effective treatment.

According to the instruction, capsules for osteoarthritis of 1-3 stages should be taken only inwards. Perform such treatment procedures should be 25 minutes before eating. In this case, the drug should be washed down with a glass of water.

Adult patients usually receive this medication in the amount of two capsules twice or thrice a day.

The duration of treatment with Kondronova is 1-2 months. If required, the course is repeated.

Adverse events

What undesirable reactions can the "Kondronova" medication cause? Instructions for use indicate that its active components have different effects on the patient's body.

Side effects when taking capsules may be:

• Because of chondroitin: allergic reactions.
• Because of glucosamine: a violation of the GIT (meteorism, epigastric pain, constipation or, conversely, diarrhea), skin allergic reactions, dizziness, pain in the legs, headache, peripheral edema, tachycardia, drowsiness and insomnia.

Drug Interactions and Overdose

The drug "Kondronova" increases the absorption of tetracyclines, and also worsens the action of glucosamine and semisynthetic penicillins. In addition, this medication is compatible with GCS and NSAIDs.

Symptoms of an overdose of Kondronova are unknown.

Capsules "Kondronova": price and similar means

Depending on the number of capsules in the package, the drug in question may have different prices (from 290 rubles).

If this medication is contraindicated to the patient, then it is replaced by one of such means as "Chondroglucid", "Teraflex" or "Artra".

Reviews

Consumer reviews about this drug are mostly positive. Patients assert that this remedy significantly improves the condition of the joints, and therefore relieve the pain associated with osteoarthritis.

The opinion of consumers is fully agreed and experienced experts. They have repeatedly been convinced of the high efficiency and effectiveness of the drug. He restores cartilaginous tissue and reduces the patient's need for NSAIDs.