Heptral - instructions for use.

The drug is available in the form of tablets with an enteric coating, and also as a solution for injections.

Tablets are whitish in color, oval in shape.

Composition:

Active substance:

• Ademethionine - 400 mg (in 1 table).

Excipients:

• Anhydrous Colloidal Silicon Dioxide
• Sodium starch glycollate
• Magnesium stearate
• Microcrystalline cellulose

Ingredients of enteric coating:

• Polyethylene glycol
• Simethicone
• Polymethacrylate
• Polysorbate
• Talc
• Purified water

Solution for injections of white color.

Composition:

Active substance:

• Ademethionine - 400 mg (in 1 bottle)

Excipients:

• Sodium hydroxide
• Water for injections
• L-lysine

Pharmacological action of the drug

The drug "Heptral" refers to hepatoprotectors, also having an antidepressant effect. In addition, ademetionine (active substance) can have cholekinetic and choleretic effects. The drug is involved in the processes of transmethylation, while donating the methyl group of phospholipids of proteins, cell membranes, neurotransmitters and hormones, then transulfation is the precursor of taurine, glutathione and cysteine. Also, ademetionine can increase the amount of glutamine in the liver, and taurine and cysteine in the blood plasma, reduce the amount of methionine in the serum, thereby normalizing the metabolic reactions in the liver.

The drug has a choleretic effect, which is due to increased polarization and mobility of liver cell membranes, due to the stimulation of the conversion of phosphatidylcholine into them. Due to this, the function of transport systems associated with the membranes of hepatocytes of bile acids, significantly improves and promotes the release of bile acids.

Hepatoprotective and choleretic effects of the drug may persist for up to three months.

Pharmacokinetics

Thanks to a special enteric coating, the tablets reach the duodenum and dissolve there. After a single dose, the maximum concentration of heptral in the blood is reached somewhere in a few hours.

When ingestion of the drug bioavailability - 5%, with intramuscular injection - 95%. The drug may be slightly associated with serum proteins. The drug can penetrate the BBB, its presence is always noted, regardless of the route of administration, in the cerebrospinal fluid.

Indications for the use of the drug "Geptral"

The instruction contains basic information on the indications for the use of preratar heptral. The use of this drug should be agreed with the doctor.

• Cholecystitis chronic
• Cholestasis intrahepatic
• Cholangitis
• Toxic liver damage
• Fatty degeneration of the liver
• Hepatitis
• Cirrhosis
• Encephalopathy
• Abstinence syndrome
• Depression

The drug can give a small toning effect, so it is not recommended to use it just before bedtime.

Side effects of the drug "Geptral"

The instruction contains exhaustive information about possible side effects of the drug.

Side effects associated with the gastrointestinal tract:

• Dyspepsia
• Heartburn
• Gastralgia

In addition, side effects may occur due to intolerance to the components of the drug.

The solution for use should be prepared immediately before injection. In the event that the color of the powder differs from that of the whitish one, it is not recommended to use it.

Contraindications

• Pregnancy
• Lactation
• Age to 18 years

If heptral is assigned to patients with cirrhosis, they will need daily monitoring of the amount of nitrogen in the blood. In addition, prolonged therapy requires monitoring, and creatinine, and urea.

Overdose means "Heptral"

The instruction does not have information about cases of overdose with this drug.

Drug Interactions of Heptral Medication

The instruction has no information about the effects of any interactions of heptral with other drugs.