"Coronale": indications for use, testimonials. Drug analogues

The development of diseases of the cardiovascular system occurs slowly and imperceptibly at the first stages. The person in most cases learns about his problems with the heart when the pathology is already progressing, as a result of which urgent hospitalization is necessary. Diseases of the heart are dangerous because they occur almost without symptoms. They are one of the main factors of mortality on earth. Even if the patient survives an attack of heart disease, he will hardly be able to return to a normal way of life, and therefore one must adapt to a new, more limited style. It is possible to prevent the development of serious complications of heart diseases by diagnosing them in time. Therefore, it is necessary to undergo preventive examinations in order to maintain health to your heart.

Heart Disease

There are several signs that may indicate the development of heart problems. Noticing such symptoms, you should immediately go to the clinic, where a thorough examination will help diagnose the disease and prevent possible complications.

The most common symptoms of the initial stages of heart disease include increased fatigue and general weakness. They can be associated with stress or increased stress, but can also be a signal of the development of heart failure. As a rule, fatigue does not go away even after rest, and it adds to it a sense of oppression, a decrease in appetite, a poor general state of the body. The second symptom that can signal the development of pulmonary or cardiac insufficiency is shortness of breath, and it can arise even when a person is in a state of absolute tranquility.

Strong fear, stress or prolonged physical activity in every healthy person can cause a rapid heartbeat, and this is considered the norm. If the tachycardia worries frequently and without any valid reasons, then we can talk about the presence of violations in the state of the cardiovascular system. Other symptoms of heart disease include loss of balance or sudden dizziness, fainting, discomfort and chest pain. Such signs give an occasion to a person to visit a doctor. And undergo a comprehensive examination of the cardiovascular system.

The drug "Coronal"

If a patient has been diagnosed with heart disease at a stage that does not require surgical intervention, he is prescribed medication. Preparations from heart diseases help the patient cope with the symptoms of pathology and slow down its development. A person needs to be prepared for the fact that if he plans to extend his life, he needs to change its image, in particular, to abandon bad habits, to eat right, to combine moderate loads with rest.

Today on the shelves of pharmacies a lot of different drugs, whose action is aimed at fighting heart problems. One of the most common medicines that are prescribed by doctors are the Coronal tablets. Indication for the use of the drug may be: coronary heart disease, arrhythmia, hypertension, ventricular or supraventricular extrasystole, and others. Before you start treatment with the drug, you need to consult a doctor. The medicine "Coronale" has a strong enough effect on the body, has a list of contraindications and can cause side effects. Produced in coated tablets. The doctor can prescribe both the "Coronal" and its analogues.

Pharmacology

The drug "Coronale" has antianginal, hypotensive and antiarrhythmic effect. This selective beta-blocker reduces the formation of cyclic AMP from ATP and is able to block beta-adrenergic receptors of the heart. Also, the drug Coronal helps reduce myocardial contractility and heart rate, its conduction and excitability.

The hypotensive effect of the drug is manifested in the fact that it helps to reduce the minute volume of blood. "Coronale" - pills that restore the normal sensitivity of baroreceptors, inhibit the activity of the renin-angiotensin system, affect the central nervous system. In patients who suffer from hypertension, the hypotensive effect is observed after 2-5 days after the onset of use. After 1-2 months a stable hypotensive therapeutic effect is observed.

The drug "Coronal", the indications for the use of which have a fairly wide spectrum, has an antianginal effect. Tablets contribute to diastole lengthening, improve the perfusion of the heart muscle, reduce its need for oxygen by reducing the heart rate. The antiarrhythmic effect of the drug is manifested in its ability to eliminate arrhythmogenic factors. Under its influence, atrioventricular conduction is slowed down and the rate of excitation of sinus and ectopic rhythm drivers decreases.

The use of the medium in medium dosages acts less pronounced on peripheral arteries, smooth muscles of the bronchi, pancreas, skeletal muscles, carbohydrate metabolism. The drug does not retain sodium ions in the body, its absorption is about 80-90%.

Indications for use

Before taking "Coronale", you should consult a doctor who will give clear instructions regarding the dosage and frequency of receptions. You can not start taking the drug yourself, there is a risk of harming your health, and with irreversible consequences.

The drug "Coronal" indications for use are most often limited to arterial hypertension and coronary heart disease. The daily dose of the drug is 5 mg. The main active substance of the drug Coronale is bisoprolol. The maximum daily rate can reach 20 milligrams, and for patients with a violation of the normal functioning of the liver - 10 milligrams. The dose of the drug in all cases is adjusted individually, taking into account the therapeutic effectiveness and heart rate. Reduce the dose of the drug "Coronale" should be gradual, you can not stop taking the course suddenly. This is especially true for patients with angina pectoris (IHD).

Contraindications

There is a list of cases in which it is better to abandon the use of the drug Coronale. Indications for use in heart disease can not be the only factor in order to begin treatment. The doctor should carefully and comprehensively examine the patient for the safety of the latter.

The drug is contraindicated in patients with decompensated CHF, acute heart failure, cardiogenic shock, cardiomegaly, Prinzmetal angina, SWS syndrome, atrioventricular blockade of the 2nd-3rd degree, and sinoatrial blockade. Do not take Coronal to patients who have an individual hypersensitivity to the drug. It is not recommended to appoint it to women during lactation, and also combine with the use of MAO inhibitors.

In extreme cases, but very carefully use the drug to treat patients with myasthenia, intermittent claudication, Raynaud's syndrome , hepatic insufficiency, CHF, pheochromocytoma, metabolic acidosis, bronchial asthma, pulmonary emphysema, diabetes mellitus. Contraindications to use may be depression, psoriasis, thyrotoxicosis, children and the elderly, pregnancy. Justify the reception of the drug "Coronale" (the doctors' reviews agree on this), pregnancy can only happen when the benefit to the mother is several times higher than the risk for the child.

Overdose

The patient must strictly follow the prescription of the specialist, because an overdose can cause dangerous symptoms. Among the common signs that are caused by an overdose of the "Coronal" - bronchospasm, heart failure, arterial hypotension, bradycardia. Intoxication causes a strong cardiodepressive effect, which prevails over a decrease in contractility and a decrease in the frequency of cardiac contractions. The patient may develop a breathing disorder caused by bronchospasm.

If a patient has an unnatural reaction to a drug, immediate measures should be taken to neutralize them. The first thing to do is to wash the stomach with the subsequent intake of enterosorbents (activated charcoal). You also need to drink a laxative remedy (sodium sulfate). Eliminate the symptoms of intoxication by administering atropine (0.5 -2.0 mg) intravenously. Also in such cases, glucagon 1-5 mg is used. When bronchospasm occurs, a bronchodilator drug (Salbutamol or Fenoterol) should be used.

Side effects

The drug "Coronale" can cause side effects, acting on the entire body. In the risk zone are:

• the cardiovascular system;
• nervous system;
• respiratory system;
• Gastrointestinal tract;
• Urogenital system;
• Visual apparatus;
• Skin, muscles, joints.

From the side of the cardiovascular system, complications such as paresthesia, conduction disorders, bradycardia, orthostatic hypertension, and lowering of arterial pressure can occasionally be observed. In patients with Raynaud's syndrome or with intermittent claudication, symptomatology worsens.

The drug "Coronal" side effects can cause and from the nervous system, namely: mental changes, bright dreams, sleep disorder, dizziness, headache, increased fatigue. Very rarely, but still, the Coronal can affect the visual apparatus. Reviews of such cases are accrued, but as a result of exposure to the drug, vision can deteriorate, tear can decrease, up to the development of conjunctivitis.

Symptoms such as bronchospasm, shortness of breath, rhinitis and nasal congestion can disturb those who suffer from bronchial asthma. In rare cases, there is a hepatotoxic effect of bisoprolol, which is determined by nausea, diarrhea, constipation, and abdominal pain.

Among the other side effects caused by the action of the drug Coronale, the patients' reviews are noted as: sweating, itching and redness of the skin, arthropathy, cramps and muscle pain. Rarely disturbed by dysuria and erectile dysfunction caused by the action of the drug Coronale. Analogues of the drug are also capable of causing side effects on the body. Therefore, in each individual case it is necessary to consult with a doctor and follow his instructions.

special instructions

In addition to contraindications and side effects, there are a number of cases where the drug should be used very carefully and certainly under the supervision of a doctor. This primarily applies to conditions such as congestive heart failure, diabetes mellitus, depression, myasthenia gravis, psoriasis, thyrotoxicosis, abnormal liver or kidney function, metabolic acidosis, starvation, Prinzmetal angina.

In chronic obstructive airways diseases, Coronal, analogs and other beta-blockers can be taken, but only in combination with bronchodilators and in minimal doses. With pheochromocytoma, the agent must be taken concomitantly with the blockade of alpha-adrenergic receptors. Dosage should be appointed after studying violations of the liver and kidneys.

The arterial hypertension can be treated with the drug only under regular medical supervision. Reduced adrenergic counterregulation and anaphylactic reaction aggravate the course of reactions in patients who take beta-blockers. In elderly patients, there may be increased sensitivity, even with the usual dose of the drug, so you also need constant monitoring.

If it is necessary to carry out a planned surgical intervention, then the drug is canceled 48 hours before the operation, while doing this not immediately, but gradually. If the patient has indications for use to the Coronal preparation, he needs to be very cautious in activities that require high speed of physical and mental reactions (work at height, car maintenance, work with dangerous mechanisms, driving, etc.).

Drug Interactions

Taking "coronale" (tablets) simultaneously with other medicines, you need to take precautions. In particular, this refers to the combination with MAO inhibitors, since after the termination there is an increase in blood pressure. Combining beta-blockers with allergen extracts for skin tests and allergens that are used for immunotherapy, there is a risk of provoking severe allergic reactions.

When using antiarrhythmic drugs І and ІІІ classes ("Dizopiramid", "Sotalol", "Quinidine", "Amiodarone", "Lidocaine") also need to be careful. With the simultaneous administration of antihypertensive drugs and "Coronal" tablets, the latter can potentiate the effects of the former. If you use this drug in combination with Guafacin, Digitalilis, Clonidine, and Reserpine, this can lead to a slowing down of electrical impulses through the conduction system of the heart .

The therapeutic efficacy of Coronal may decrease as a result of sympathomimetic agents (antitussive drugs, nasal or eye drops). Activators of hepatic enzymes provoke a reduction in the biological half-life of the beta-adrenergic receptor. Simultaneous reception of antiarrhythmic drugs and calcium channel blockers groups "Nifedipina" and "Verapamil" can cause the development of bradycardia, heart failure or conduction disorders.

Simultaneous treatment with drugs "Coronale" and "Clonidine" can cause the development of hypertensive crisis. If the indication of "Coronal" is available in patients with diabetes mellitus, it is highly recommended to regularly monitor blood glucose levels. This is due to the fact that beta-blockers are able to potentiate the action of antidiabetic drugs and insulin, masking signs of hypoglycemia.

Reviews about the medicine

The drug "Coronal" doctors appoint patients with heart disease. But does this drug act on everyone? Analyzing reviews about him, you can make a general conclusion that the effect of the medicine on the patient's body depends on each individual case. Those who had the good fortune not to face side effects are very positive about the "Coronal" preparation. Reviews of patients who have experienced the effects of the drug are less than welcome. However, problems can be avoided. Before taking Coronal (tablets), the instructions to it should be re-read carefully and several times, because inattention can also harm your health.

The first thing that patients note is a decrease in the pulse, a slight decrease in blood pressure, an improvement in the general condition of the patient. After several months of use, doctors recommend lowering the dose, because the pulse and pressure have already reached the norm and there is no need to lower them even more. Also, patients note that if you adhere to all the prescriptions of the attending physician, then the unpleasant consequences of using the drug should not be feared. But those who independently decided to change the daily dose or did not warn the doctor about the use of other medicines, faced complications that in a number of cases required the hospitalization of the patient. Therefore, do not forget that there is an instruction manual for each Coronal tablets.

Analogues

The drug "Coronal" has a wide range of analogues - drugs, in which there are the same active substances. All of them differ in price, country of production, mechanism of exposure, contraindications, presence or absence of side effects.

Like any medicine, Coronal also has its own sphere of application. Analogues of it are similar in that active substance at them - bisoprolol. The most common are preparations of domestic production. Their advantage is low price (compared to imported) and high efficiency. In particular, you can note such drugs: "Aritel", "Aritel Kor", "Biprol", "Bisoprolol", "Bisoprolol-Prana", "Niperten". They are available in every pharmacy kiosk, and their price ranges from 30 to 100 rubles per package.

Import analogues of the preparation Coronal are also presented in a wide range: Bidop (Hungary), Biol (Slovenia), Bisogamma (Germany), Bisocard (Poland), Bizomor (India), Bisoprolol- Lugal "(Ukraine)," Bisoprolol-Teva "(Israel) and others. Especially popular among imported drugs is the German medicine Concor. Its price is 4 times higher than the cost of the drug Coronal and is about 180 rubles. In general, imported drugs in pharmacy kiosks are offered at prices ranging from 300 to 600 rubles per package.