The drug "Tamoxifen" instructions for use refers to a group of antitumor drugs that have a non-steroidal and anti-estrogenic effect. The use of this agent stimulates the release of pituitary hormones, removes the inflammatory process and effectively stops the development of neoplasms. Starting with the first dose, the drug blocks the action of estrogens for several weeks without causing unwanted side effects associated with excessive tissue growth. In male patients suffering from ejaculation disorder, the use of "Tamoxifen" can provoke an increase in the concentration of testosterone in the plasma. If we consider the pharmacokinetics of this antineoplastic agent, then it begins to act actively after only thirty minutes after administration, reaching the highest values within five to seven hours.
The preparation "Tamoxifen" is available in the form of yellow tablets containing ten, twenty, thirty or forty milligrams of tamoxifen citrate as the main component. Additional ingredients are: cellulose, sodium starch, magnesium stearate, povidone and lactose. The shell contains in its composition polyethylene glycol, titanium dioxide and hypromellose. In addition, lactose is present in a small amount in the medicine.
To prescribe the reception of "Tamoxifen" tablets, the instruction for use recommends patients with endometrial, prostatic or ovarian, breast and breast cancer. Also, this drug is very effective for tumors in the kidney or melanoma. With sarcoma, you should also start taking Tamoxifen. Instructions for use notes and positive results from its use for the treatment of nodular formations of various etiologies.
Take this antitumor agent categorically prohibited in the case of individual intolerance citrate tamoxifen or any other constituents of the drug. Leukopenia, thrombophlebitis, pregnancy, lactation period, cataract and severe forms of cardiovascular diseases are also contraindications to the appointment of this drug "Tamoxifen" - the instruction for use draws attention to this. In addition, it should not be taken to patients with hepatic or renal insufficiency. With extreme caution appoint tablets "Tamoxifen" with thrombocytosis, thrombocytopenia, brain diseases or hypercalcemia.
Taking this medication in some groups of patients can cause dyspepsia, nausea, vomiting, cholestasis, decreased appetite, diarrhea and liver infiltration. Confusion, thrombocytopenia, headache, leukopenia, drowsiness, fever and dizziness can also occur as a result of taking "Tamoxifen" tablets. Side effects include the risk of uterine bleeding, burning and itching in the genitals, cystic tumors, urticaria, dermatitis and bronchospasm. In addition, there may be a decrease in potency, vaginal discharge, skin rash and hyperemia.