"Trimetazidine-Biocom MB": instructions for use, composition, analogues and reviews

The drug has an effect that manifests itself by accelerating the metabolic processes occurring in the neurosensory organs and in the myocardium. Before starting therapy, you need to find out what the drug "Trimetazidine-Biocom MB" is. Instructions for use, the composition of the medication - useful information, which should be read.

Form of release of the drug, its components

The drug belongs to the means with modified release, it is released in the form of tablets in a shell, it is made on the basis of trimetazidine dihydrochloride. The blister contains 10 tablets, in the pack of them can be from 1 to 6. One tablet contains 35 mg of the main component. The composition is supplemented with magnesium stearate, povidone, aerosil, hypromellose and calcium hydrogen phosphate dihydrate.

Titanium dioxide, macrogol belong to the components of the tablet shell "Trimetazidin-Biocom MB". Instruction for use informs that in addition to these substances, the membrane consists of hypromellose and red iron oxide.

pharmachologic effect

The antihypoxic agent allows to return normal metabolism to cells in which negative changes occurred due to the development of a pathological condition (ischemia, hypoxia). Tablets exclude the reduction in the amount of ATP inside cells, improve the state of ion membrane channels, transmembrane movement of sodium and potassium ions. It is possible to maintain cellular homeostasis during the treatment with the use of the drug "Trimetazidine-Biocom MB". Instruction for use informs that the preparation reduces the rate with which the oxidative process of fatty acids occurs, due to which more active oxidation of glucose is carried out, myocardium is protected from ischemia. The action of the drug is based on switching the oxidation process from fatty acids to glucose.

The drug, supporting the normal course of metabolic processes, positively affects the neurosensory organs and the heart, reduces the severity of disturbances in the ionic transmembrane flow in the development of ischemia. By affecting the heart tissue, the drug helps to reduce such indicators as migration, infiltration of polynucleated neutrophils. Regarding the action of the drug "Trimetazidine-Biocom MB", the instructions for use include data that show a positive effect on the myocardium damaged by ischemia. On hemodynamics, the drug has absolutely no effect.

Pharmacokinetics

Absorption occurs almost completely and quickly. The connection with plasma proteins is insignificant (16%), the bioavailability index is 90%. From the moment of taking the pill to the moment when the level of the active substance in the body becomes the maximum, it takes about two hours. It is known that the drug easily passes through the histohematetic barriers. Half-life is carried out in about five hours. The medicine is removed from the body by the kidneys, most of it does not change its shape.

Indications

"Trimetazidine-Biocom MB" (tablets) instruction allows you to use for the long-term treatment of IHD. Its purpose is shown in the following cases:

• The need for the implementation of preventive measures in the occurrence of angina attacks;
• Dizziness, the presence of which is associated with vascular lesions;
• Cochlear-vestibular disorders having ischemic nature (worsening of the hearing organs);
• Chorioretinal vascular pathology accompanied by ischemia.

Prevention of angina pectoris can be performed with the use of a single medicine or by implementing complex therapy.

Contraindications

Regarding the cases when the administration of the drug "Trimetazidine-Biocom MB" is undesirable, the instructions for use, the reviews contain data showing the impossibility of treatment with a drug under such conditions:

• Excessive sensitivity to the main component and other ingredients of the agent;
• Breast-feeding;
• Period of bearing of the child.

Since the safety of use of the drug in childhood (less than 18 years) and the effectiveness of treatment with its use have not been established, these patients are not prescribed this drug.

The drug is contraindicated in severe violations of liver function and kidney failure, in which such an indicator as creatinine clearance is significantly reduced (15 ml / min or less). Not only indications and contraindications determine the possibility of treatment with the drug "Trimetazidine-Biocom MB". The cost also has a certain value in the choice of medicament for the implementation of therapy. We'll talk about it a little later.

Treatment with drug

The size of a single dose is determined by the doctor (usually not less than 40 mg, but not more than 60). In a day it is required to perform 2-3 reception of a remedy. The duration of therapy is set separately for different cases.

Adverse events

Before proceeding to therapy, it is necessary to familiarize yourself with possible unwanted reactions of the body due to taking the tablets "Trimetazidine-Biocom MB". Instructions for the use of the remedy on which the treatment is based, to side effects, include allergy, which is manifested as an itch and skin rash, other reactions that are not the norm for the body. In the process of treatment in very rare cases, some patients experience nausea, vomiting occurs, gastralgia is noted.

Cases of severe overdose have not been documented, and the possibility of their occurrence is unlikely. As a result of exceeding the recommended dose, there may be hyperemia of the face, hypotension.

special instructions

Treatment does not interfere with the ability to drive and does not interfere with activities that require rapid physical and psychomotor reactions.

Tablets are not suitable for the removal of angina attacks and can be used only for preventive purposes by patients who suffer from such attacks.

Against the background of treatment in patients with coronary heart disease , the daily requirement for nitrates decreases.

The cost of the drug, analogs, reviews

The instruction for use should be studied before beginning treatment with Trimetazidine. The price is also important information and is taken into account when choosing a drug for the treatment (prevention) of heart problems (IHD). Approximate cost of the medicine is 100-165 rubles. For 30 tablets and 189-208 rubles. For 60 tablets.

As an analogue, you can apply "Preductal", "Antistene" or "Trimet." Possible treatment with Medarum, Rimecor. The doctor can replace the medicine, appointing "Prekard", "Angiozil", "Trimitar MV." There is a possibility of treatment with "Triducard", "Premedin", "Trimectal" or "Metagard". Judging by the reviews, the most popular analogue is Preductal, this drug is effective, but it costs more than Trimetazidine. Instructions for use, the price show that treatment with the drug is beneficial, reviews confirm the effectiveness of such therapy.

In the responses about the medication it is reported that the drug well removes pain in the heart, its task performs perfectly. As a result of taking the medication, according to patients and doctors, there are positive changes, for example, the body of people who have undergone therapy, better perceives physical activity. Many people claim that after a few days of treatment they have shortness of breath, tachycardia passes, blood pressure indicators come back to normal. Usually, improvements are noted on the fourth day of treatment, based on the use of the drug Trimetazidine-Biocom MB. Instructions for use, the price show that the drug is not only affordable, but also effective, in addition it has a minimum number of possible undesirable reactions that usually do not develop. Occurrence of side effects is observed in rare cases.

So, we gave exhaustive information about the preparation "Trimetazidine-Biocom MB". Analogues, price, instructions, reviews about the drug you are now known. The drug should be prescribed by a specialist and used in the prescribed dosage. The need to replace a medicine is also determined by the doctor on the basis of many factors. Observance of all the recommendations makes it possible to make the treatment most effective without harm to health.