The drug "Tioktatsid." Instructions

The medication "Tioktatsid", the instruction indicates, is released in two forms: a solution intended for intravenous administration and tablets. The drug is included in the clinical and pharmacological group of products with antioxidant properties, regulates the exchange of lipids and carbohydrates.

The active substance of the solution is tiokta trometamol, in one ampoule - 952.3 mg. In terms of tioctovuyu - 600 mg. The active substance of the tablets is thioctic acid.

The pharmacological action is provided by the metabolic properties of the preparation, the biochemical mechanism of action is similar to that of the vitamin B group. Thioctic acid performs functions related to the protection of cells from the toxic effect of free radicals formed as a result of metabolism. The drug destroys toxic compounds of exogenous origin.

The medicine "Tioktatsid 600" increases the concentration of antioxidant glutathione, reducing the manifestations of polyneuropathy. In addition, the drug is characterized by a hepatoprotective, hypocholesterolemic, hypolipidemic, hypoglycemic effect. Displays glucose and improves the work of neurons.

In the body of thiocyate, trometamol decomposes by oxidation and conjugation into metabolic components, which are up to 90% excreted by the kidneys.

The drug "Tioktatsid." Instructions for indications

The drug is prescribed in the following cases.

1. With diabetic polyneuropathy.

2. With polyneuropathy caused by alcoholism.

The drug "Tioktatsid." Dosing instructions

With polyneuropathy, taking place in severe form, the doctor prescribes intravenous administration once a day. Establishes a daily dose of 600 mg, which corresponds to the 1st ampoule of the drug "Tioktatsid 600". Treatment with the drug in the solution lasts from 2 to 4 weeks, then the course continues with tablets in the previous dose of 600 mg.

Before administration, the solution of trometamole thiokate is diluted in a special solution of sodium chloride with a concentration of 0.9% for 30 minutes. To prepare the drug for infusion, 100-200 mg of sodium chloride is used. It is important when preparing the solution to protect the vessel from the drug from getting light. To this end, the bottle is wrapped with aluminum foil, and the medicine is considered suitable for use for 6 hours.

The procedure is carried out slowly, for 1 minute is injected into the vein no more than 2 ml. If it is performed by a perfusor, the administration time should be greater than 12 minutes.

Ampoules with tiotetamol tiocetate are very sensitive to light.

The drug "Tioktatsid." Instructions. Side effects

During clinical trials, allergic reactions were observed less frequently than in 1 patient per 10,000, manifested by skin rashes, hives, itching, eczema, redness of the skin, anaphylactic shock.

Convulsions and diplopia, disorders in the nervous system were observed less often than in 1 patient per 10,000.

Failures in the functioning of the hematopoiesis system were observed less frequently than in 1 patient per 10 000, manifested by purpura, spot hemorrhages, tendency to bleeding, thrombocytopathy, thrombophlebitis.

Disorders in the work of the digestive system, the drug "Tioktatsid 600 t" was rare: less than 1 patient per 100 showed a change in taste; Less than 1 patient out of 1 000 showed nausea and vomiting.

Rapid administration of the drug may cause increased pressure, difficulty breathing. The general state of the patient's body after the administration of thioctic acid deteriorated in 1 patient per 10,000.

When appointing a medicine "Tioktatsid 600 t" the doctor should take into account contraindications to its use: pregnancy, lactation, children's age, hypersensitivity.

The medicine "Tioktatsid." Instructions. special instructions

The effectiveness of the drug is significantly reduced with the simultaneous intake of alcohol. Abstinence from drinking is a prerequisite for a course of therapy. When treating diabetic polyneuropathy, you need to monitor the optimal concentration of sugar in the blood.