The preparation is Progestogel. Feedback and how to use it

Ointment "Progestogel" is used externally. The drug is translucent, colorless, homogeneous, has a characteristic smell of alcohol. The active ingredient is micronized natural progesterone.

The drug "Progestogel" (feedback from experts confirm this) contributes to the blocking of estrogen receptors. As a result, the absorption from the tissues of the fluid increases, the compression of the milk ducts decreases. The active component of the agent blocks the prolactin receptors in the tissues of the mammary gland and leads to a decrease in lactopoiesis (maintenance of lactation).

With local use of the drug "Progestogel" (doctors' reviews also confirm this), a high concentration of progesterone is created at the site of application. The medication does not have a systemic effect, which helps to avoid side effects.

The mechanism of its action is based on an increase in the content in the tissues of the mammary glands of progesterone. Progesterone, in turn, lowers the expression of estrogen receptors by stimulating the production of enzymes that convert by the oxidation of estradiol to estrone, which exhibits less activity.

Through the transdermal route of use, gestagen affects the condition of the vasculature and glandular epithelium. This reduces the permeability of capillaries, reduces swelling in the tissues of the mammary glands, eliminates the signs of mastalgia.

Absorption of the active ingredient during skin application is about ten percent of the dose. The drug "Progestogel" (doctors' reviews confirm this) does not break down in the liver on the way to the mammary gland.

When the dosage is reduced with transdermal (cutaneous) application, it is possible to create a high concentration at the application site (exceeding in 10 times the content in the systemic blood flow).

Secondarily, the drug is metabolized in the liver, and conjugates with sulfuric and glucuronic acids are formed.

Ten percent of the drug is excreted with bile, about fifty to sixty - with urine.

Means "Projesto". Indication. Mode of application

The drug is prescribed for mastodinia, diffuse fibrocystic mastopathy.

It is recommended to apply one application of the gel to the area of the mammary glands with the aid of an applicator-doser. The drug is applied until completely absorbed. It should be used every day once or twice or in the second phase of the cycle (from the sixteenth to the twenty-fifth day). Therapeutic course - up to three cycles. Repeated use is allowed only on the advice of a doctor.

When using the medication, there may be soreness in the mammary glands, metrorrhagia, hot flashes, a decrease in libido. Possible and allergic reactions, swelling of the neck and lips, nausea, headache, fever, erythema on the site of application.

The drug "Progestogel" (doctors' reviews are unambiguous in this) should not be prescribed for nodular forms of fibrocystic mastopathy, tumors in the mammary gland of an unexplained nature, monotherapy of breast or genital cancers . Contraindicated agent "Progestogen" in pregnancy, as well as hypersensitivity to its components.