The medicine "Doxazosin". Instructions for use and description

Medication "Doxazosin", the price of which is from 80 rubles, has antihypertensive, vasodilating activity, has spasmolytic, hypolipidemic effect. By reducing the muscle tone of the vessels, the pressure and overall peripheral vascular resistance are lowered. Under the influence of medication, a decrease in the level of HDL cholesterol, total cholesterol, triglycerides, inhibition of platelet aggregation and an increase in the concentration in tissues of active plasminogen are noted. Dexazosin (instructions for use confirms this information) helps to reduce pressure and resistance in the urethra, in the internal sphincter. After intake, the medicine is absorbed well enough. Absorption of medication is 80-90%. When eating, the absorption decreases by one hour. The maximum concentration is achieved in three hours, with evening reception - after five hours. Bioavailability of the drug - 60-70%. Metabolism occurs fairly quickly in the liver cells. The drug is withdrawn in unmodified form with urine and in the form of metabolites through the intestine.

The drug is Doxazosin. Instructions for use. Appointment

The drug is recommended for arterial hypertension as an additional remedy or as a mono drug. As part of the combined treatment, the medication is prescribed with beta-blockers, thiazide diuretics, ACE inhibitors and others. Indications include hyperplasia of the prostate of a benign nature (against normal or elevated blood pressure).

Contraindications

The medicine "Doxazosin" (instructions for use warns of this) is not prescribed until the age of eighteen, during lactation, with hypersensitivity, during the antenatal period.

Adverse Reactions

During therapy (especially at its initial stages), orthostatic hypotension may occur , leading in some cases to fainting. To prevent this condition, it is recommended to avoid sudden changes in body position. The drug "Doxazosin" (instructions for use indicates this) can cause dizziness, dry mouth, rhinitis, headache, arrhythmia. On the basis of the reception there is tachycardia, drowsiness, arthralgia, tenderness in the chest, cerebrovascular disorders. To undesirable consequences of the therapy include increased fatigue, allergic reactions, attacks of angina pectoris, nausea, skin rash, urinary incontinence, nosebleeds, heart attack.

Dosing regimen

Medication Doxazosin instructions for use in hypertension recommends starting to take a single dose of 1 mg (before bedtime). Subsequently, the amount of the drug is increased to 16 mg / day. After taking the drug should be in a lying position for at least six to eight hours to prevent the syndrome of the "first dose". In case of insufficient effect, the increase in dosage is carried out after 1-2 weeks to 2 mg. At intervals of seven to fourteen days, the amount of the drug is increased by 2 mg. Treatment of prostatic hyperplasia occurs in a dose of 2 to 4 mg per day. The maximum dosage is eight milligrams per day.