Sulfasalazine. Instructions for use

The drug "Sulfasalazin EN" is an anti-inflammatory, antirheumatic, immunosuppressive, bacteriostatic intestinal. The mechanism of drug exposure is based on the properties of the active components.

The active substance of salazosulfapyridine is an antibiotic from the group of sulfonamides. The component has bacteriostatic activity in relation to gonococcus, streptococcus, diplococcus, E. coli.

The active component of 5-aminosalicylic acid has an anti-inflammatory property, promotes inhibition of prostaglandin synthesis and suppression of cyclooxygenase.

"Sulfasalazine" ( application instruction contains such information) blocks transformation in lymphocytes and inhibits monocytes. The drug affects both cellular and humoral immunity.

Medication is poorly absorbed from the digestive tract.

The drug "Sulfasalazin" instruction for use recommends for ulcerative proctitis, nonspecific colitis (ulcerative). In these pathologies, medication is used in the treatment of exacerbations and as maintenance therapy in the remission phase.

"Sulfasalazine" is recommended for use in Crohn's disease (with moderate and mild forms during the exacerbation phase).

The drug is also prescribed for rheumatoid arthritis (juvenile including).

The medication "Sulfasalazine" instructions for use recommends taking after meals. Dosage should be set individually according to the severity of the symptoms, as well as possible side effects.

Usually, adults are prescribed from 500 to 2000 milligrams four times a day to facilitate the manifestation of pathology. Subsequently, the patient is transferred to supportive care. Dosage at the same time - 500 milligrams three to four times a day. The duration of therapy is several months.

Dosage for children: from five to seven years - 250-500 milligrams from three to six times a day, from seven years - to 0.5 grams three to six times a day.

For adults, the therapeutic dosage is 1.5-3 grams. As practice shows, the effect comes after six or ten weeks. Therapy continues for at least six months.

The drug is contraindicated in anemia, porphyria, severe disorders in the liver or kidneys, hypersensitivity (including salicylates, sulfonamides). Do not prescribe the drug "Sulfasalazine" to children under five years of age. Contraindication is the period of lactation. If it is necessary to use the medication while breastfeeding, the question of stopping lactation should be resolved .

During pregnancy, the drug may be prescribed strictly according to the indications in the minimum therapeutic dosage under medical supervision. It is not recommended to take the drug "Sulfasalazine" in the third trimester of pregnancy.

Most of the side effects of the drug depend on the dosage taken and is the result of the activity of salazosulfapyridine (the active substance).

The medicine can provoke peripheral nephropathy, dizziness, interstitial nephritis, sleep disorders, tinnitus. During treatment, there may be abnormalities in kidney activity, diarrhea, thrombocytopenia, pulmonary lesions, leukopenia, infertility and oligospermia (transient). To adverse reactions also include vomiting, pancreatitis, agranulocytosis, anaphylactic shock, anemia, urticaria. In rare cases, there may be disorders in the functions of the nervous peripheral system, skin reactions.

During the use of the drug it is recommended to use a large amount of liquid.

There is no evidence that the medicament "Sulfasalazine" has analogs for the active ingredient.

Before using the medication, experts recommend reading the annotation.